A Turnkey Screening Solution for Identifying Hepatotoxic Compounds
3D InSight™ Liver Human Microtissues are the gold-standard for liver toxicity testing. These pharma-validated, preclinical co-culture liver models have been shown to achieve 2x higher sensitivity for DILI prediction compared to traditional 2D hepatocytes. Because they combine multi-donor diversity with structural and functional robustness, these models are ideal for drug safety and efficacy testing as well as the study of healthy and diseased liver function.
Microtissues are shipped in Akura™ 96 plates (one microtissue per well), with 3D InSight™ Human Liver Microtissue Maintenance Medium - AF, our recommended medium for routine culture and maintenance of liver microtissues. You can also request 3D InSight™ Human Liver Microtissue Medium - TOX, which we recommend for hepatotoxity testing applications.
For 384 liver plates, mono-cultures or XL sized microtissues please contact us directly.
- Reflect the average response of a population with a model incorporating hepatocytes from 5 male and 5 female donors
- Achieve the highest biological relevance in an in vitro model with primary hepatocyte, Kupffer cell, and liver endothelial cell (LEC) co-cultures
- Test long-term effects of drug exposure in an organotypic, functional liver model
- Highly reproducible and robust liquid handling in InSphero’s patented Akura™ 96 plates (engineered to protect microtissues from accidental aspiration)
- Complete turnkey solutions offers lower cost-of-ownership than in-house production
- PHH from pooled male/female donors
- Co-culture with Kupffer cells and LECs
- Guaranteed 28 days viability
- 96-well format, 1 microtissue per well
- Delivered with min. 50 mL of 3D InSight™ Liver Maintenance Medium
- Biweekly production. Check our online production schedule for details
- Shipping date to be confirmed by our customer service team after checkout
Q: When do I get my product?
A: We produce 3D InSight™ Human Liver Microtissues every two weeks. (Check the Liver Microtissue Production Schedule for upcoming production runs.) After your order is completed, our customer service team will contact you by email to notify you of the next shipping dates.
Q: How do you ship?
A: We ship our microtissues in a patent-pending shipping container that maintains the microtissue functionality and integrity perfectly. The transport method depends on the destination country. Typically, the microtissues ship via companies such as Fedex, UPS, DHL or direct commercial airline flights such as Swiss Air. When you place your order, please choose an appropriate ship-to address and contact name so the microtissues will be delivered promptly to your lab.
Q: Where are the microtissues produced?
A: The microtissues are produced in our production facility in Schlieren, Switzerland outside of Zurich.
Q: Will I receive a shipment tracking number?
A: If the microtissues ship via Fedex, UPS, DHL you will receive a tracking number. If the shipment travels via a direct commercial flight you will receive notification of departure and scheduled arrival date. InSphero monitors the shipment until delivery.
Q: What do I get with my order of microtissues?
A: InSphero’s microtissues are delivered in an Akura™ plate designed for protecting microtissues during media changes, dosings and other treatments. Each shipment includes maintenance media, a USB temperature logger confirming successful transport temperature and InSphero’s Quick Start Guide providing instructions for handling microtissues upon arrival. Each plate of microtissues also comes with a specialized lid for maintaining an optimal cell culture environment. Quality Control release data is provided via email after delivery along with images of each microtissue.
As a user of InSphero’s liver microtissues you will also receive the password to our Customer Portal where you will find protocols and other helpful details for successful microtissue studies.
Q: What should I do with the microtissues upon arrival?
A: Open the outer box and retrieve the temperature logger from the internal microtissue box. Press Start/Stop button on the monitor to view confirmation that appropriate temperature was maintained during transport. Change the media upon arrival or place the microtissues in a 37⁰C incubator until you can change the media. Follow instructions in the Quick Start Guide for microtissue maintenance upon arrival. Additional instructions can be found in InSphero’s microtissue handling guide.
Q: What toxicology studies and assays can I run with my liver microtissues?
A: See InSphero’s website at link below for examples of hepatotoxicity data generated with InSphero’s 3D liver microtissues.
Q: Why should I use InSphero microtissues?
A: Our standardized, scaffold-free liver microtissues are engineered and manufactured to the highest quality specifications using our 3D Select™ process in sate of the art facilities by our staff of 3D experts in toxicology and metabolic diseases. Receiving our assay-ready, user-friendly format means you can focus your resources on generating more relevant data in 3D models.
InSphero General Terms and Conditions of Sale
Prior to placing an order on this page, we recommend that you first read the InSphero Terms and Conditions. This document includes our disclaimer, imprint, and detailed terms and conditions information. PDF version.
Shipping costs will be calculated based on the quantity of plates ordered and the shipping destination. Our service team will contact you to review order details and verify ship dates prior to confirming your order.
Curious how we ship live, assay-ready 3D microtissues to labs world-wide?