Description
Assay-Ready 3D InSight™ Beagle Dog Liver Microtissues
Accelerate your drug discover and development with Assay-Ready 3D InSight™ Beagle Dog Liver Microtissues out of the box. Skip model development, our pre-aggregated, physiologically relevant microtissues are ready to use.
- Assay-Ready Format: Each Akura™ 96 Plate contains uniform (1 microtissue per well), pre-aggregated co-culture spheroids of primary beagle dog hepatocytes (single donor) with non-parenchymal liver cells (single donor).
- Long-Term Viability: Up to 4 weeks of functional stability, supporting flexible assay scheduling and long-term studies at your site.
- Standardized, Scalable & Reproducible: Produced every three weeks (Production Schedule) using standardized manufacturing & high QC to ensure minimal batch-to-batch variability and consistent results.
- Reliable Shipping & Handling: Delivered in our InFloat™ Shipping System which includes our Akura™ 96 Plates with 3D InSight™ Dog Liver Microtissue Maintenance Medium TOX, our recommended medium for routine culture and maintenance of liver microtissues.
Note: This product is offered only as a bundle including Beagle Dog Liver Microtissues and the appropriate medium type (250 ml). Minimum order of Assay-Ready 3D InSight™ Beagle Dog Liver Microtissues is 2 plates.
If you need an even number of plates, please request a quote.
Catalog No.: MT-02-003-04
Learn more about the product and access resources:
Technical Specifications
Technical Specifications
- Primary beagle dog hepatocytes - single donor, sex dependent on the ongoing lot
- Co-culture with non-parenchymal liver cells (single donor, sex dependent on the ongoing lot), including but not limited to Kupffer cells and LECs
- Pre-aggregated 1 microtissue per well in Akura™ 96 Spheroid Microplate
- Cultured in 3D InSight™ Dog Liver Maintenance Medium
- Guaranteed 4 weeks of functional viability & stability
- Size: Diameter between 235 - 335 μm
Medium
Medium
3D InSight™ Dog Liver Maintenance Medium - TOX (250 ml) for toxicity testing, included
Catalog No.: CS-07-030-02
Please refer to this Medium Selection Guide for more information.
Shipping
Shipping
Our award-winning InFloat™ System enables global delivery of 3D InSight™ Beagle Dog Liver Microtissues in a temperature- and humidity-controlled environment.
Check out the Quick Start Guide - how to handle Liver Microtissues upon arrival.
Shipping costs will be calculated based on the quantity of the plates ordered and the shipping destination. Our service team will contact you to review order details and verify ship dates prior to confirming your order.
Disclaimer: InSphero guarantees that in all plates shipped all wells destined to be filled contained microtissues when packed for transport. This is confirmed via optical scans of each plate shipped. On rare occasions during transport, a few microtissues may be damaged. InSphero uses a protective packaging system to minimize microtissue loss due to shipping and handling and guarantees ≥ 95% of microtissues will be available for use upon arrival at customer site.
InSphero Sales Terms and Conditions
InSphero Sales Terms and Conditions
Prior to placing an order on this page, we recommend that you first read the InSphero Terms and Conditions. This document includes our disclaimer, imprint, and detailed terms and conditions information.
FAQs
FAQs
Q: When do I get my Microtissues?
A: We produce 3D InSight™ Beagle Dog Microtissues every three weeks. (Check the Liver Microtissue Production Schedule for upcoming production runs.) Order based on our production schedule, our customer service team will contact you by email to notify you of the next shipping date.
Q: How do you ship?
A: We ship our Beagle Dog Liver Microtissues in InFloat™ System that maintains the microtissue functionality and integrity perfectly. The transport method depends on the destination country.
Typically, the Beagle Dog Liver Microtissues ship via companies such as Fedex, UPS, and DHL or direct commercial airline flights such as Swiss. When you place your order, please choose an appropriate ship-to address and contact name so the microtissues will be delivered promptly to your lab.
Q: Where are the 3D InSight™ Beagle Dog Liver Microtissues produced?
A: The microtissues are produced in our production facility in Schlieren, Switzerland outside of Zurich.
Q: Will I receive a shipment tracking number?
A: If the microtissues ship via Fedex, UPS, or DHL you will receive a tracking number. If the shipment travels via a direct commercial flight you will receive a notification of departure and scheduled arrival date. InSphero monitors the shipment until delivery.
Q: What should I do with the Microtissues upon arrival?
A: Open the outer box and retrieve the temperature logger from the internal microtissue box. Press Start/Stop button on the monitor to view confirmation that the appropriate temperature was maintained during transport. Change the media upon arrival or place the microtissues in a 37⁰C incubator until you can change the media.
Follow the instructions in the Quick Start Guide for microtissue maintenance upon arrival. Additional instructions can be found in the Product Manual .
Q: What toxicology studies and assays can I run with my Beagle Dog Liver Microtissues?
A: See InSphero’s website with this link for examples of hepatotoxicity data generated reports with InSphero’s 3D liver microtissues.
Below the link to some resources:
- Poster: Leveraging Human, Animal Liver Microtissues and Low-Input RNA-Sequencing to Characterize Mechanism of Drug-Induced Liver Injury
- Paper: Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model
- Paper: Transcriptomic analysis in liver spheroids identifies a dog-specific mechanism of hepatotoxicity for amcenestrant
- Webinar: The 3D InSight™ Liver Microtissue Platform a Versatile Tool for In Vitro Hepatotoxicity Studies
Q: Why should I use InSphero's 3D InSight Microtissues?
A: Our standardized, scaffold-free Microtissues are engineered and manufactured to the highest quality specifications using our 3D Select process in state-of-the-art facilities by our staff of 3D experts in toxicology and metabolic diseases.
Receiving our assay-ready, user-friendly format means you can focus your resources on generating more relevant data in 3D models.